芍藥苷返回列表頁

參考價:500

具體成交價以合同協(xié)議為準(zhǔn)

型號
HY-N0293
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

25mg 500元 10000支可售

在線詢價加入對比查看聯(lián)系電話

聯(lián)系方式：鄧女士查看聯(lián)系方式

更新時間：2024-06-26 12:02:33瀏覽次數(shù)：123次

聯(lián)系我時，請告知來自制藥網(wǎng)

CAS號	23180-57-6	產(chǎn)地	國產(chǎn)
規(guī)格	25mg	級別	化工級
證書	ISO系列證書

CAS號

23180-57-6

產(chǎn)地

國產(chǎn)

規(guī)格

25mg

級別

化工級

證書

ISO系列證書

Paeoniflorin (Synonyms: 芍藥苷; Peoniflorin)

Paeoniflorin 是一種 heat shock protein 誘導(dǎo)化合物，普遍存在于芍藥科植物中，具有多種生物活性，包括抗ai活性、抗yan活性、增強(qiáng)認(rèn)知能力和減弱學(xué)習(xí)障礙、抗氧化應(yīng)激、抗血小板聚集、擴(kuò)張血管和降低血液粘度。

生物活性

Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity^[1]^[2]^[3].

體外研究(In Vitro)

Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70^[3].

Western Blot Analysis^[3]

Cell Line:	HeLa and IMR-32 cells
Concentration:	80 μg/mL
Incubation Time:	4, 8, 12, 16, and 24 hours
Result:	Promoted the phosphorylation of HSF1.

體內(nèi)研究(In Vivo)

Paeoniflorin (intradermal injection; 25 and 100mg/kg; once daily; 20 days) shows favorable effects on experimental arthritis^[4].

Animal Model:	SD rats with collagen induced arthritis^[4]
Dosage:	25 and 100mg/kg
Administration:	Intradermal injection; 25 and 100mg/kg; once daily; 20 days
Result:	Decreased arthritis score, relieved ankle and paw swelling, improved spleen istopathology, decreased the levels of IgA, IgM, IgG and anti-CII antibody.

分子量：480.46

Formula：C₂₃H₂₈O₁₁

CAS 號：23180-57-6

中文名稱：芍藥苷；芍藥甙

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

In Vitro:

DMSO : 100 mg/mL (208.13 mM; Need ultrasonic)

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.0813 mL	10.4067 mL	20.8134 mL
5 mM	0.4163 mL	2.0813 mL	4.1627 mL
10 mM	0.2081 mL	1.0407 mL	2.0813 mL

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
2.

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
3.

請依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

參考文獻(xiàn)

[1]. Yan-Xi Zhou, et al. A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother. 2020 Oct;130:110505.

[2]. Yongjing Xiang, et al. Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities. J Pharm Pharmacol. 2020 Apr;72(4):483-495.

[3]. Dai Yan, et al. Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones. 2004 Winter;9(4):378-89. Int J Oncol. 2013 Nov;43(5):1643-51.

[4]. Pei-Pei Li, et al. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141(1):290-300.

注：產(chǎn)品僅用于科研